LYMPHOID NEOPLASIA The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia: results from the GMALL study group
نویسندگان
چکیده
1Charité Universitätsmedizin Berlin, Campus Benjamin Franklin (CBF), Medizinische Klinik III, Berlin; 2Institut für Pharmazeutische Biologie/ZAFES/Diagnostikzentrum für Akute Leukämie (DCAL), Goethe-Universität, Frankfurt/Main; 3Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ), Braunschweig; 4Medizinische Klinik II, Universitätsklinikum Schleswig-Holstein (UKSH), Campus Kiel, Kiel; 5Max Planck-Institut (MPI) für Molekulare Genetik, Berlin; and 6Goethe-Universität, Medizinische Klinik II, Frankfurt, Germany
منابع مشابه
The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia: results from the GMALL study group.
MLL translocations in adult B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) are largely restricted to the immature CD10(-) immunophenotypes. MLL-AF4 is known to be the most frequent fusion transcript, but the exact frequencies of MLL aberrations in CD10(-) adult BCP-ALL are unknown. We present a genetic characterization of 184 BCR-ABL(-) CD10(-) adult ALL cases (156 cyIg(-), 28 cyIg(+...
متن کاملCD10-negative pre-B acute lymphoblastic leukemia (ALL): a distinct high-risk subgroup of adult ALL associated with a high frequency of MLL aberrations. Results of the German Multicenter Trials for Adult ALL (GMALL) Running title: CD10-negative pre-B ALL
Immunophenotyping disclosed CD10 negativity in 70 of 2,408 cases of B-lineage acute lymphoblastic leukemia (ALL), although other criteria followed classification of pre-B ALL (e.g., cytoplasmic immunoglobulin positivity). These blasts showed high myeloid antigen expression (60% CD65-positivity) and reacted with antibody 7.1 in 95% of the cases. MLL-AF4 fusion transcripts and/or an 11q23/MLL rea...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Brief report CD10 pre-B acute lymphoblastic leukemia (ALL) is a distinct high-risk subgroup of adult ALL associated with a high frequency of MLL aberrations: results of the German Multicenter Trials for Adult ALL (GMALL)
Immunophenotyping disclosed CD10 negativity in 70 of 2408 cases of B-lineage acute lymphoblastic leukemia (ALL), although other criteria followed classification of pre-B ALL (eg, cytoplasmic immunoglobulin positivity). These blasts showed high myeloid antigen expression (60% CD65 positivity) and reacted with antibody 7.1 in 95% of the cases. MLL-AF4 fusion transcripts or an 11q23/MLL rearrangem...
متن کاملDiversity of T-cell receptor Gene Rearrangements in South Indian Patients with Common Acute Lymphoblastic Leukemia
Background: Precursor B-Acute Lymphoblastic Leukemia (precursor B-ALL) oc-curs due to the uncontrolled proliferation of B-lymphoid precursors arrested at a par-ticular stage of B-cell development. Precursor-B-ALL is classified mainly into pro-B-ALL, common-ALL and pre-B-ALL. The Common Acute Lymphoblastic Antigen CD10 is the marker for common-ALL. Objective: This study was aimed to examine the ...
متن کاملInvolvement of the MLL gene in adult T-lymphoblastic leukemia.
While the MLL "recombinome" is relatively well characterized in B-cell precursor acute lymphoblastic leukemia (BCP ALL), available data for adult acute T-lymphoblastic leukemia (T-ALL) are scarce. We performed fluorescence in situ hybridization (FISH) for an MLL split signal on 223 adult T-ALL samples obtained within the framework of the German Multicenter ALL 07/2003 therapy trial. Three biphe...
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